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The TRAF2-p62 axis promotes proliferation and survival of liver cancer by activating mTORC1 pathway

20 Apr 2023

Abstract excerpt

TRAF2 (Tumor necrosis factor receptor-associated factor 2) is a dual function protein, acting as an adaptor protein and a ubiquitin E3 ligase, which plays an essential role in mediating the TNFα-NFκB signal pathway. Dysregulated expression of TRAF2 has been reported in a variety of human cancers. Whether and how TRAF2 regulates the growth of liver cancer cells remains elusive. The goal of this study is to...

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PMID: 37081115
DOI: 10.1038/s41418-023-01164-7

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