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Article

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling.

Nature cell biology - 1 Sept 2002

Gao Xinsheng, Zhang Yong, Arrazola Peter, Hino Okio, Kobayashi Toshiyuki, Yeung Raymond S, Ru Binggeng, Pan Duojia

Abstract excerpt

Target of Rapamycin (TOR) mediates a signalling pathway that couples amino acid availability to S6 kinase (S6K) activation, translational initiation and cell growth. Here, we show that tuberous sclerosis 1 (Tsc1) and Tsc2, tumour suppressors that are responsible for the tuberous sclerosis syndrome, antagonize this amino acid-TOR signalling pathway. We show that Tsc1 and Tsc2 can physically associate with TOR and...

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Identifiers

PMID: 12172555
DOI: 10.1038/ncb847

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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