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Article

Dysregulated renin-angiotensin system contributes to acute lung injury caused by hind-limb ischemia-reperfusion in mice.

Shock (Augusta, Ga.) - 1 Nov 2013

Chen Li-Nan, Yang Xiu-Hong, Nissen Daniel H, Chen Yan-Yan, Wang Li-Jun, Wang Jian-Hui, Gao Jun-Ling, Zhang Lian-Yuan

Abstract excerpt

The mechanism of acute lung injury (ALI) following limb ischemia-reperfusion (LIR) is not yet clear. We speculate that the unbalanced expression of angiotensin-converting enzymes (ACE and ACE2) and angiotensins [Ang II and Ang-(1-7)] in the renin-angiotensin system (RAS) is a major cause of ALI. To prove this hypothesis, pathological changes, lung edema, and permeability of wild-type mice at different time points...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23903854
DOI: 10.1097/SHK.0b013e3182a6953e

Genes

ACE2
ACE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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