Article
Strain-specific differences in sensitivity to ischemia-reperfusion lung injury in mice.
Journal of applied physiology (Bethesda, Md. : 1985) - 1 May 2006
Dodd-o Jeffrey M, Hristopoulos Maria L, Welsh-Servinsky Laura E, Tankersley Clarke G, Pearse David B
Abstract excerpt
Ischemia-reperfusion (I/R) lung injury is characterized by increased pulmonary endothelial permeability and edema, but the genetic basis for this injury is unknown. We utilized an in vivo mouse preparation of unilateral lung I/R to evaluate the genetic determinants of I/R lung injury. An index of pulmonary vascular protein permeability was measured by the ratio of left-to-right lung Evans blue dye of eight inbred...
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