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Article

Hypoxia-inducible factor plays a gut-injurious role in intestinal ischemia reperfusion injury.

American journal of physiology. Gastrointestinal and liver physiology - 1 May 2011

Kannan Kolenkode B, Colorado Iriana, Reino Diego, Palange David, Lu Qi, Qin Xiaofa, Abungu Billy, Watkins Anthony, Caputo Francis J, Xu Da-Zhong, Semenza Gregg L, Deitch Edwin A, Feinman Rena

Abstract excerpt

Gut injury and loss of normal intestinal barrier function are key elements in the paradigm of gut-origin systemic inflammatory response syndrome, acute lung injury, and multiple organ dysfunction syndrome (MODS). As hypoxia-inducible factor (HIF-1) is a critical determinant of the physiological and pathophysiological response to hypoxia and ischemia, we asked whether HIF-1 plays a proximal role in the induction...

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Identifiers

PMID: 21183660
DOI: 10.1152/ajpgi.00459.2010
PMCID: PMC3094138

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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