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Article

Predicting functional consequences of SNPs on mRNA translation via machine learning.

Nucleic acids research - 25 Aug 2023

Li Zheyu, Chen Liang

Abstract excerpt

The functional impact of single nucleotide polymorphisms (SNPs) on translation has yet to be considered when prioritizing disease-causing SNPs from genome-wide association studies (GWAS). Here we apply machine learning models to genome-wide ribosome profiling data to predict SNP function by forecasting ribosome collisions during mRNA translation. SNPs causing remarkable ribosome occupancy changes are named...

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Identifiers

PMID: 37427781
DOI: 10.1093/nar/gkad576
PMCID: PMC10450169

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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