Article
[Attempts at analyzing the initiation of the initial processes of carcinogenesis based on the Xiphophorus melanoma model].
Archiv fur Geschwulstforschung - 1 Jan 1990
Anders A, Anders F, Zechel C, Schleenbecker U, Smith A
Abstract excerpt
Certain backcross hybrids (BC8-22) of a spotted X. maculatus (platyfish) and a non-spotted X. helleri (swordtail; recurrent parent) are highly sensitive to mutagenic carcinogens and, after a latent period of 8 to 12 months, develop melanoma of unicellular origin that is genealogically related to the spots of the platyfish. Sensitivity to the carcinogen or susceptibility to melanoma, respectively, are inherited in...
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