The fruit fly Drosophila and the fish Xiphophorus as model systems for cancer studies.

Abstract excerpt

Genetic and molecular analyses of Drosophila have shown that tumorigenesis may arise from inactivation of single genes controlling cell growth and differentiation. Recessive mutations in a series of genes interrupt the differentiation of primordial cells and result in overgrowth, producing either hyperplasia or neoplasia. In mutant animals tumours form in either the optic centres of the larval brain, the imaginal...

Topics

• Animals
• Cyprinodontiformes
• Disease Models, Animal
• Drosophila
• Gene Expression Regulation, Neoplastic
• Melanoma
• Mutation
• Neoplasms, Experimental
• Phenotype