Associations between a polymorphism in the pleiotropic GCKR and Age-related phenotypes: the HALCyon programme.

doi:10.1371/journal.pone.0070045

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Article

Associations between a polymorphism in the pleiotropic GCKR and Age-related phenotypes: the HALCyon programme.

PloS one - 1 Jan 2013

Alfred Tamuno, Ben-Shlomo Yoav, Cooper Rachel, Hardy Rebecca, Deary Ian J, Elliott Jane, Harris Sarah E, Kivimaki Mika, Kumari Meena, Power Chris, Starr John M, Kuh Diana, Day Ian N M

Abstract excerpt

BACKGROUND: The glucokinase regulatory protein encoded by GCKR plays an important role in glucose metabolism and a single nucleotide polymorphism (SNP) rs1260326 (P446L) in the gene has been associated with several age-related biomarkers, including triglycerides, glucose, insulin and apolipoproteins. However, associations between SNPs in the gene and other ageing phenotypes such as cognitive and physical...

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PMID: 23894584
DOI: 10.1371/journal.pone.0070045
PMCID: PMC3720952

Genes

GCKR

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Associations between a polymorphism in the pleiotropic GCKR and Age-related phenotypes: the HALCyon programme.PMID 23894584Read ↗

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The n-3 long-chain PUFAs modulate the impact of the GCKR Pro446Leu polymorphism on triglycerides in adolescents.Semantic proximity Read ↗

Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations.Semantic proximity Read ↗

The GCKR-P446L gene variant predisposes to raised blood cholesterol and lower blood glucose in the P446L mouse-a model for GCKR rs1260326Semantic proximity Read ↗

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