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Article

Associations between a polymorphism in the pleiotropic GCKR and Age-related phenotypes: the HALCyon programme.

PloS one - 1 Jan 2013

Alfred Tamuno, Ben-Shlomo Yoav, Cooper Rachel, Hardy Rebecca, Deary Ian J, Elliott Jane, Harris Sarah E, Kivimaki Mika, Kumari Meena, Power Chris, Starr John M, Kuh Diana, Day Ian N M

Abstract excerpt

BACKGROUND: The glucokinase regulatory protein encoded by GCKR plays an important role in glucose metabolism and a single nucleotide polymorphism (SNP) rs1260326 (P446L) in the gene has been associated with several age-related biomarkers, including triglycerides, glucose, insulin and apolipoprote...

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Identifiers

PMID: 23894584
DOI: 10.1371/journal.pone.0070045
PMCID: PMC3720952

Genes

GCKR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23894584-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Associations between a polymorphism in the pleiotropic GCKR and Age-related phenotypes: the HALCyon programme.PMID 23894584Read ↗

Pleiotropic Effects of Common and Rare GCKR Exonic Mutations on Cardiometabolic Traits.Semantic proximity Read ↗

The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population.Semantic proximity Read ↗

A multi-cohort study of polymorphisms in the GH/IGF axis and physical capability: the HALCyon programme.Semantic proximity Read ↗

The n-3 long-chain PUFAs modulate the impact of the GCKR Pro446Leu polymorphism on triglycerides in adolescents.Semantic proximity Read ↗

Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations.Semantic proximity Read ↗

The GCKR-P446L gene variant predisposes to raised blood cholesterol and lower blood glucose in the P446L mouse-a model for GCKR rs1260326Semantic proximity Read ↗

Triglyceride response to an intensive lifestyle intervention is enhanced in carriers of the GCKR Pro446Leu polymorphism.Semantic proximity Read ↗

Genetic evidence for the effects of glucokinase activation on frailty-related outcomes: A Mendelian randomisation study.Semantic proximity Read ↗

Age, Gene/Environment Susceptibility-Reykjavik Study: multidisciplinary applied phenomics.Semantic proximity Read ↗

GCKR common functional polymorphisms are associated with metabolic syndrome and its components: a 10-year retrospective cohort study in Iranian adultsSemantic proximity Read ↗

Association of rs780094 in GCKR with metabolic traits and incident diabetes and cardiovascular disease: the ARIC Study.Semantic proximity Read ↗

Associations between APOE and low-density lipoprotein cholesterol genotypes and cognitive and physical capability: the HALCyon programme.Semantic proximity Read ↗

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