Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A multi-cohort study of polymorphisms in the GH/IGF axis and physical capability: the HALCyon programme.

PloS one - 1 Jan 2012

Alfred Tamuno, Ben-Shlomo Yoav, Cooper Rachel, Hardy Rebecca, Cooper Cyrus, Deary Ian J, Gaunt Tom R, Gunnell David, Harris Sarah E, Kumari Meena, Martin Richard M, Sayer Avan Aihie, Starr John M, Kuh Diana, Day Ian N M

Abstract excerpt

BACKGROUND: Low muscle mass and function have been associated with poorer indicators of physical capability in older people, which are in-turn associated with increased mortality rates. The growth hormone/insulin-like growth factor (GH/IGF) axis is involved in muscle function and genetic variants in genes in the axis may influence measures of physical capability. METHODS: As part of the Healthy Ageing across the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anthropometry
Share to Hand Strength

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Health

Share to Human Growth Hormone

Share to Insulin-Like Growth Factor I

Share to Insulin-Like Growth Factor II

Share to Motor Activity

Share to Postural Balance

Source

Open in PubMed Open full text

Identifiers

PMID: 22253814
DOI: 10.1371/journal.pone.0029883
PMCID: PMC3254646

Genes

GHR
IGF1
IGF2
IGFBP3
IRS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A multi-cohort study of polymorphisms in the GH/IGF axis and physical capability: the HALCyon programme.PMID 22253814Read ↗

Genetic markers of bone and joint health and physical capability in older adults: the HALCyon programme.Semantic proximity Read ↗

The phenotypic and genotypic association of grip strength with frailty, physical performance and functional limitations over time in older adults.Semantic proximity Read ↗

Associations between a polymorphism in the pleiotropic GCKR and Age-related phenotypes: the HALCyon programme.Semantic proximity Read ↗

Genetic Associations with Aging Muscle: A Systematic Review.Semantic proximity Read ↗

GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium.Semantic proximity Read ↗

Association of rs35767 polymorphism in the IGF1 gene with athletic performance in power and endurance sports: A meta-analysis.Semantic proximity Read ↗

Identifying Factors Associated with Lower Quarter Performance-Based Balance and Strength Tests: the Project Baseline Health StudySemantic proximity Read ↗

Interactions among IGF-1, AKT2, FOXO1, and FOXO3 variations and between genes and physical activities on physical performance in community-dwelling elders.Semantic proximity Read ↗

Insulinlike Growth Factor-1 and Its Binding Protein-3 Polymorphisms Predict Circulating IGF-1 Level and Appendicular Skeletal Muscle Mass in Chinese Elderly.Semantic proximity Read ↗

IGF-II gene region polymorphisms related to exertional muscle damage.Semantic proximity Read ↗

Genetic variation in human muscle strength--opportunities for therapeutic interventions?Semantic proximity Read ↗

Associations between APOE and low-density lipoprotein cholesterol genotypes and cognitive and physical capability: the HALCyon programme.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.