Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations.

doi:10.2337/db08-0516

Article

Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations.

Diabetes - 1 Nov 2008

Orho-Melander Marju, Melander Olle, Guiducci Candace, Perez-Martinez Pablo, Corella Dolores, Roos Charlotta, Tewhey Ryan, Rieder Mark J, Hall Jennifer, Abecasis Goncalo, Tai E Shyong, Welch Cullan, Arnett Donna K, Lyssenko Valeriya, Lindholm Eero, Saxena Richa, de Bakker Paul I W, Burtt Noel, Voight Benjamin F, Hirschhorn Joel N, Tucker Katherine L, Hedner Thomas, Tuomi Tiinamaija, Isomaa Bo, Eriksson Karl-Fredrik, Taskinen Marja-Riitta, Wahlstrand Björn, Hughes Thomas E, Parnell Laurence D, Lai Chao-Qiang, Berglund Göran, Peltonen Leena, Vartiainen Erkki, Jousilahti Pekka, Havulinna Aki S, Salomaa Veikko, Nilsson Peter, Groop Leif, Altshuler David, Ordovas Jose M, Kathiresan Sekar

Abstract excerpt

OBJECTIVE: Using the genome-wide association approach, we recently identified the glucokinase regulatory protein gene (GCKR, rs780094) region as a novel quantitative trait locus for plasma triglyceride concentration in Europeans. Here, we sought to study the association of GCKR variants with metabolic phenotypes, including measures of glucose homeostasis, to evaluate the GCKR locus in samples of non-European...

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Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations.

Abstract excerpt

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