Article
The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population.
Diabetes - 1 Aug 2008
Vaxillaire Martine, Cavalcanti-Proença Christine, Dechaume Aurélie, Tichet Jean, Marre Michel, Balkau Beverley, Froguel Philippe
Abstract excerpt
OBJECTIVE: Hepatic glucokinase (GCK) is a key regulator of glucose storage and disposal in the liver, where its activity is competitively modulated, with respect to glucose, by binding to glucokinase regulatory protein (GCKR) in the presence of fructose 6-phosphate. Genome-wide association studies for type 2 diabetes identified GCKR as a potential locus for modulating triglyceride levels. We evaluated, in a...
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