Article
Triglyceride response to an intensive lifestyle intervention is enhanced in carriers of the GCKR Pro446Leu polymorphism.
The Journal of clinical endocrinology and metabolism - 1 Jul 2011
Pollin Toni I, Jablonski Kathleen A, McAteer Jarred B, Saxena Richa, Kathiresan Sekar, Kahn Steven E, Goldberg Ronald B, Altshuler David, Florez Jose C
Abstract excerpt
CONTEXT: Glucokinase regulatory protein (GCKR) regulates the trafficking and enzymatic activity of hepatic glucokinase, the rate-limiting enzyme in glycogen synthesis and glycolysis. The intronic single-nucleotide polymorphism (SNP) rs780094 (intron 16) and the missense SNP rs1260326 (P446L) in the GCKR gene are strongly associated with increased circulating triglyceride and C-reactive protein levels and,...
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