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Article

Pleiotropic Effects of Common and Rare GCKR Exonic Mutations on Cardiometabolic Traits.

Genes - 10 Mar 2022

Yeh Kuan-Hung, Hsu Lung-An, Teng Ming-Sheng, Wu Semon, Chou Hsin-Hua, Ko Yu-Lin

Abstract excerpt

BACKGROUND: The common non-synonymous mutation of the glucokinase regulator (GCKR) gene, namely rs1260326, is widely reported to have pleiotropic effects on cardio-metabolic traits and hematological parameters. OBJECTIVE: This study aimed to identify whether other GCKR variants may have pleiotropic effects independent of the rs1260326 genotypes. METHODS: In total, 81,097 Taiwan Biobank participants were enrolled...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35328045
DOI: 10.3390/genes13030491
PMCID: PMC8951277

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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