Article
Apaf1 is required for mitochondrial pathways of apoptosis and brain development.
Cell - 18 Sept 1998
Yoshida H, Kong Y Y, Yoshida R, Elia A J, Hakem A, Hakem R, Penninger J M, Mak T W
Abstract excerpt
Apoptosis is essential for the precise regulation of cellular homeostasis and development. The role in vivo of Apaf1, a mammalian homolog of C. elegans CED-4, was investigated in gene-targeted Apaf1-/- mice. Apaf1-deficient mice exhibited reduced apoptosis in the brain and striking craniofacial a...
Topics
- Animals
- Apoptosis
- Apoptotic Protease-Activating Factor 1
- Brain
- Brain Chemistry
- Caspase 2
- Caspase 3
- Caspase 8
- Caspase 9
- Caspases
- Cells, Cultured
- Cysteine Endopeptidases
- Cytochrome c Group
- Embryo, Mammalian
- Enzyme Precursors
- Fibroblasts
- Gene Expression
- Head