Article
Apaf1 is required for mitochondrial pathways of apoptosis and brain development.
Cell - 18 Sept 1998
Yoshida H, Kong Y Y, Yoshida R, Elia A J, Hakem A, Hakem R, Penninger J M, Mak T W
Abstract excerpt
Apoptosis is essential for the precise regulation of cellular homeostasis and development. The role in vivo of Apaf1, a mammalian homolog of C. elegans CED-4, was investigated in gene-targeted Apaf1-/- mice. Apaf1-deficient mice exhibited reduced apoptosis in the brain and striking craniofacial abnormalities with hyperproliferation of neuronal cells. Apaf1-deficient cells were resistant to a variety of apoptotic...
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