Article
Apaf-1 deficiency and neural tube closure defects are found in fog mice.
Proceedings of the National Academy of Sciences of the United States of America - 14 Aug 2001
Honarpour N, Gilbert S L, Lahn B T, Wang X, Herz J
Abstract excerpt
The forebrain overgrowth mutation (fog) was originally described as a spontaneous autosomal recessive mutation mapping to mouse chromosome 10 that produces forebrain defects, facial defects, and spina bifida. Although the fog mutant has been characterized and available to investigators for several years, the underlying mutation causing the pathology has not been known. Because of its phenotypic resemblance to...
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