Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of Aif function causes cell death in the mouse embryo, but the temporal progression of patterning is normal.

Proceedings of the National Academy of Sciences of the United States of America - 27 Jun 2006

Brown Doris, Yu Benjamin D, Joza Nicholas, Bénit Paule, Meneses Juanito, Firpo Meri, Rustin Pierre, Penninger Josef M, Martin Gail R

Abstract excerpt

Apoptosis-inducing factor (AIF) is an evolutionarily conserved, ubiquitously expressed flavoprotein with NADH oxidase activity that is normally confined to mitochondria. In mammalian cells, AIF is released from mitochondria in response to apoptotic stimuli and translocates to the nucleus where it is thought to bind DNA and contribute to chromatinolysis and cell death in a caspase-independent manner. Here we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Patterning
Share to Cell Count

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electron Transport Complex I

Share to Embryo, Mammalian

Share to Embryonic Development

Share to Genes, Lethal

Share to Mice, Inbred Strains

Share to Mitochondria

Source

Open in PubMed Open full text

Identifiers

PMID: 16788063
DOI: 10.1073/pnas.0603950103
PMCID: PMC1502554

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of Aif function causes cell death in the mouse embryo, but the temporal progression of patterning is normal.PMID 16788063Read ↗

Apaf-1-independent programmed cell death in mouse developmentSemantic proximity Read ↗

Apaf1 apoptotic function critically limits Sonic hedgehog signaling during craniofacial development.Semantic proximity Read ↗

AIF: not just an apoptosis-inducing factor.Semantic proximity Read ↗

The molecular archaeology of a mitochondrial death effector: AIF in Drosophila.Semantic proximity Read ↗

Expression and regulation of genes associated with cell death during murine preimplantation embryo developmentSemantic proximity Read ↗

Mouse Fkbp8 activity is required to inhibit cell death and establish dorso-ventral patterning in the posterior neural tube.Semantic proximity Read ↗

Apaf1 in developmental apoptosis and cancer: how many ways to die?Semantic proximity Read ↗

Live imaging of apoptosis in a novel transgenic mouse highlights its role in neural tube closureSemantic proximity Read ↗

Disruption of the murine nuclear factor I-A gene (Nfia) results in perinatal lethality, hydrocephalus, and agenesis of the corpus callosum.Semantic proximity Read ↗

Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.Semantic proximity Read ↗

Mutation of zebrafish caf-1b results in S phase arrest, defective differentiation, and p53-mediated apoptosis during organogenesis.Semantic proximity Read ↗

Cell death in development: shaping the embryo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.