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Article

Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.

Cell - 18 Sept 1998

Cecconi F, Alvarez-Bolado G, Meyer B I, Roth K A, Gruss P

Abstract excerpt

The cytosolic protein APAF1, human homolog of C. elegans CED-4, participates in the CASPASE 9 (CASP9)-dependent activation of CASP3 in the general apoptotic pathway. We have generated by gene trap a null allele of the murine Apaf1. Homozygous mutants die at embryonic day 16.5. Their phenotype includes severe craniofacial malformations, brain overgrowth, persistence of the interdigital webs, and dramatic...

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Source

Identifiers

PMID: 9753320
DOI: 10.1016/s0092-8674(00)81732-8

Genes

APAF1
CASP3
CASP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.PMID 9753320Read ↗

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Apaf-1 deficiency and neural tube closure defects are found in fog mice.Semantic proximity Read ↗

Three new types of Apaf-1 in mammalian cells.Semantic proximity Read ↗

Endogenous Expression and Subcellular Localization of Core Apoptosis Regulators Reveal Key Differences Between Embryonic and Germline Apoptosis in C. elegansSemantic proximity Read ↗

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