Article
Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.
Cell - 18 Sept 1998
Cecconi F, Alvarez-Bolado G, Meyer B I, Roth K A, Gruss P
Abstract excerpt
The cytosolic protein APAF1, human homolog of C. elegans CED-4, participates in the CASPASE 9 (CASP9)-dependent activation of CASP3 in the general apoptotic pathway. We have generated by gene trap a null allele of the murine Apaf1. Homozygous mutants die at embryonic day 16.5. Their phenotype inc...
Topics
- Alleles
- Animals
- Apoptosis
- Apoptotic Protease-Activating Factor 1
- Brain
- Caspase 3
- Caspases
- Chimera
- Cloning, Molecular
- Craniofacial Abnormalities
- Cysteine Endopeptidases
- Embryo, Mammalian
- Enzyme Activation
- Eye Abnormalities
- Fibroblasts
- Gene Expression Regulation, Developmental
- Humans
- Hyperplasia