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Article

THAP1: Role in Mouse Embryonic Stem Cell Survival and Differentiation.

Stem cell reports - 11 Jul 2017

Aguilo Francesca, Zakirova Zuchra, Nolan Katie, Wagner Ryan, Sharma Rajal, Hogan Megan, Wei Chengguo, Sun Yifei, Walsh Martin J, Kelley Kevin, Zhang Weijia, Ozelius Laurie J, Gonzalez-Alegre Pedro, Zwaka Thomas P, Ehrlich Michelle E

Abstract excerpt

THAP1 (THAP [Thanatos-associated protein] domain-containing, apoptosis-associated protein 1) is a ubiquitously expressed member of a family of transcription factors with highly conserved DNA-binding and protein-interacting regions. Mutations in THAP1 cause dystonia, DYT6, a neurologic movement disorder. THAP1 downstream targets and the mechanism via which it causes dystonia are largely unknown. Here, we show that...

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Identifiers

PMID: 28579396
DOI: 10.1016/j.stemcr.2017.04.032
PMCID: PMC5511047

Genes

THAP1

Provenance

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