Article
Mouse Fkbp8 activity is required to inhibit cell death and establish dorso-ventral patterning in the posterior neural tube.
Human molecular genetics - 15 Feb 2008
Wong Rebecca Lee Yean, Wlodarczyk Bogdan J, Min Kyung Soo, Scott Melissa L, Kartiko Susan, Yu Wei, Merriweather Michelle Y, Vogel Peter, Zambrowicz Brian P, Finnell Richard H
Abstract excerpt
Neural tube defects (NTDs) are birth defects that can be disabling or lethal and are second in their prevalence after cardiac defects among major human congenital malformations. Spina bifida is a NTD where the spinal cord is dysplastic, and the overlying spinal column is absent. At present, the molecular mechanisms underlying the spinal bifida development are largely unknown. In this study, we present a Fkbp8...
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