Article
Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model.
Cancer cell - 2 Jun 2009
Wang Yuan, Yang Jiong, Zheng Huarui, Tomasek Gerald J, Zhang Peng, McKeever Paul E, Lee Eva Y-H P, Zhu Yuan
Abstract excerpt
Recent studies have identified genes and core pathways that are altered in human glioblastoma. However, the mechanisms by which alterations of these glioblastoma genes singly and cooperatively transform brain cells remain poorly understood. Further, the cell of origin of glioblastoma is largely elusive. By targeting a p53 in-frame deletion mutation to the brain, we show that p53 deficiency provides no significant...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.