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Article

Brain tumor stem cells maintain overall phenotype and tumorigenicity after in vitro culturing in serum-free conditions.

Neuro-oncology - 1 Dec 2010

Vik-Mo Einar Osland, Sandberg Cecilie, Olstorn Havard, Varghese Mercy, Brandal Petter, Ramm-Pettersen Jon, Murrell Wayne, Langmoen Iver Arne

Abstract excerpt

Traditional in vitro culturing of tumor cells has been shown to induce changes so that cultures no longer represent the tumor of origin. Serum-free culturing conditions are used in a variety of cancers to propagate stem-like cells in vitro. Limited reports, however, exist on the effects of such propagation. We have compared cells from brain tumor biopsies cultivated under serum-free conditions at passages 2 and...

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Identifiers

PMID: 20843775
DOI: 10.1093/neuonc/noq102
PMCID: PMC3018941

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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