Article
LRRK2 secretion in exosomes is regulated by 14-3-3.
Human molecular genetics - 15 Dec 2013
Fraser Kyle B, Moehle Mark S, Daher João P L, Webber Philip J, Williams Jeri Y, Stewart Carrie A, Yacoubian Talene A, Cowell Rita M, Dokland Terje, Ye Tong, Chen Dongquan, Siegal Gene P, Galemmo Robert A, Tsika Elpida, Moore Darren J, Standaert David G, Kojima Kyoko, Mobley James A, West Andrew B
Abstract excerpt
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset Parkinson's disease (PD). Emerging evidence suggests a role for LRRK2 in the endocytic pathway. Here, we show that LRRK2 is released in extracellular microvesicles (i.e. exosomes) from cells that natively express LRRK2. LRRK2 localizes to collecting duct epithelial cells in the kidney that actively secrete exosomes into urine. Purified...
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