Article
Mutations in the p53 tumor suppressor gene in tree shrew hepatocellular carcinoma associated with hepatitis B virus infection and intake of aflatoxin B1.
Gene - 13 Jun 2000
Park U S, Su J J, Ban K C, Qin L, Lee E H, Lee Y I
Abstract excerpt
Infection with hepadnaviruses and exposure to aflatoxin B1 (AFB1) are considered to be major risk factors in the development of hepatocellular carcinoma (HCC) in humans. A high rate of p53 mutations at codon 249 has been reported in these tumors. The tree shrew (Tupaia belangeri chinensis) is a useful animal model for the development of HCC after human hepatitis B virus (HBV) infection or AFB1 treatment....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.