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Article

Hepatic aflatoxin B1-DNA adducts and TP53 mutations in patients with hepatocellular carcinoma despite low exposure to aflatoxin B1 in southern Japan.

Liver international : official journal of the International Association for the Study of the Liver - 1 Oct 2011

Shirabe Ken, Toshima Takeo, Taketomi Akinobu, Taguchi Kennichi, Yoshizumi Tomoharu, Uchiyama Hideaki, Harimoto Norifumi, Kajiyama Kiyoshi, Egashira Akinori, Maehara Yoshihiko

Abstract excerpt

BACKGROUND & AIMS: Hepatitis B or C virus infection is considered to be the main cause of hepatocellular carcinoma (HCC) in Japan. Aflatoxin B1 (AFB1) is a carcinogen associated with HCC in regions with high exposure. Mutations in codon 249, exon 7 are a hallmark of AFB1 exposure. Therefore, to c...

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Identifiers

PMID: 21745313
DOI: 10.1111/j.1478-3231.2011.02572.x

Genes

AGT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21745313-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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