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Article

<i>Drosophila</i>SOCS36E negatively regulates JAK/STAT pathway signaling via two separable mechanisms

25 Jul 2013

Abstract excerpt

Conserved from humans to Drosophila, the Janus kinase/signal transducer and activators of transcription (JAK/STAT) signaling cascade is essential for multiple developmental and homeostatic processes, with regulatory molecules controlling pathway activity also highly conserved. We characterize the Drosophila JAK/STAT pathway regulator SOCS36E and show that it functions via two independent mechanisms. First, we...

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PMID: 23885117
DOI: 10.1091/mbc.e13-05-0275

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