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Cullin-RING Ligase 5: Functional characterization and its role in human cancers

22 Apr 2020

Abstract excerpt

Cullin-RING ligase 5 (CRL5) is a multi-protein complex and consists of a scaffold protien cullin 5, a RING protein RBX2 (also known as ROC2 or SAG), adaptor proteins Elongin B/C, and a substrate receptor protein SOCS. Through targeting a variety of substrates for proteasomal degradation or modulating various protein-protein interactions, CRL5 is involved in regulation of many biological processes, such as...

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PMID: 32334051
DOI: 10.1016/j.semcancer.2020.04.003

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