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Article

Therapeutic Implication of SOCS1 Modulation in the Treatment of Autoimmunity and Cancer

11 Apr 2019

Abstract excerpt

The suppressor of cytokine signaling (SOCS) family of intracellular proteins has a vital role in the regulation of the immune system and resolution of inflammatory cascades. SOCS1, also called STAT-induced STAT inhibitor (SSI) or JAK-binding protein (JAB), is a member of the SOCS family with actions ranging from immune modulation to cell cycle regulation. Knockout of SOCS1 leads to perinatal lethality in mice and...

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Identifiers

PMID: 31105556
DOI: 10.3389/fphar.2019.00324

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