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Article

The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families.

Genes & development - 15 Dec 1998

Kamura T, Sato S, Haque D, Liu L, Kaelin W G, Conaway R C, Conaway J W

Abstract excerpt

The Elongin BC complex was identified initially as a positive regulator of RNA polymerase II (Pol II) elongation factor Elongin A and subsequently as a component of the multiprotein von Hippel-Lindau (VHL) tumor suppressor complex, in which it participates in both tumor suppression and negative regulation of hypoxia-inducible genes. Elongin B is a ubiquitin-like protein, and Elongin C is a Skp1-like protein that...

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Identifiers

PMID: 9869640
DOI: 10.1101/gad.12.24.3872
PMCID: PMC317264

Genes

VHL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families.PMID 9869640Read ↗

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Regulation of cytokine-inducible SH2-containing protein (CIS) by ubiquitination and Elongin B/C interaction.Semantic proximity Read ↗

Formation of the VHL-elongin BC tumor suppressor complex is mediated by the chaperonin TRiC.Semantic proximity Read ↗

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