Article
The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families.
Genes & development - 15 Dec 1998
Kamura T, Sato S, Haque D, Liu L, Kaelin W G, Conaway R C, Conaway J W
Abstract excerpt
The Elongin BC complex was identified initially as a positive regulator of RNA polymerase II (Pol II) elongation factor Elongin A and subsequently as a component of the multiprotein von Hippel-Lindau (VHL) tumor suppressor complex, in which it participates in both tumor suppression and negative r...
Topics
- Amino Acid Sequence
- Animals
- Ankyrins
- Binding Sites
- Carrier Proteins
- Cell Line
- Consensus Sequence
- Elongin
- Enzyme Stability
- Gene Expression Regulation
- Janus Kinase 2
- Mice