Article

SOCS2 physiological and pathological functions

2015-12-28

Abstract excerpt

Suppressors of cytokine signalling (SOCS) proteins are modulators of cytokine and growth factor signalling whose aberrant regulation has been linked to a variety of inflammatory and neoplastic diseases. SOCS proteins are able to act as substrate-recruiting component of E3-ubiquitin ligase complexes and target interacting proteins for degradation. At least some of the family members can also directly inhibit tyrosi...

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Literature Corpus work: bd8a6aa8-733a-55c0-989c-7fcc42211df7
DOI: 10.2741/760

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