Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Unravelling the druggability and immunological roles of the SOCS-family proteins

29 Nov 2024

Abstract excerpt

The Suppressor of Cytokine Signalling (SOCS) protein family play a critical role in cytokine signalling and regulation of the JAK/STAT pathway with functional consequences to the immune response. Members of this family are implicated in multiple different signalling cascades that drive autoimmune diseases and cancer, through their binding to phosphotyrosine modified proteins as well as ubiquitination activity as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to interferon and immune responses
Share to PI3K/AKT/mTOR signaling in cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39676878
DOI: 10.3389/fimmu.2024.1449397

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Unravelling the druggability and immunological roles of the SOCS-family proteinsPMID 39676878Read ↗

SOCS Proteins in Immunity, Inflammatory Diseases, and Immune-Related CancerSemantic proximity Read ↗

SOCS2: physiological and pathological functions.Semantic proximity Read ↗

SOCS2 physiological and pathological functionsSemantic proximity Read ↗

SOCS1: a potent and multifaceted regulator of cytokines and cell‐mediated inflammationSemantic proximity Read ↗

SOCS: suppressors of cytokine signalling.Semantic proximity Read ↗

Therapeutic Implication of SOCS1 Modulation in the Treatment of Autoimmunity and CancerSemantic proximity Read ↗

SOCS, Inflammation, and AutoimmunitySemantic proximity Read ↗

<i>Drosophila</i>SOCS ProteinsSemantic proximity Read ↗

SOCS signaling in autoimmune diseases: Molecular mechanisms and therapeutic implicationsSemantic proximity Read ↗

SOCS proteins, cytokine signalling and immune regulationSemantic proximity Read ↗

Dissociating STAT4 and STAT5 Signaling Inhibitory Functions of SOCS3: Effects on CD8 T Cell Responses.Semantic proximity Read ↗

One gene to rule them all – clinical perspectives of a potent suppressor of cytokine signaling – SOCS1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.