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Exploring the CK2 Paradox: Restless, Dangerous, Dispensable

20 Jan 2017

Abstract excerpt

The history of protein kinase CK2 is crowded with paradoxes and unanticipated findings. Named after a protein (casein) that is not among its physiological substrates, CK2 remained in search of its targets for more than two decades after its discovery in 1954, but it later came to be one of the most pleiotropic protein kinases. Being active in the absence of phosphorylation and/or specific stimuli, it looks...

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PMID: 28117670
DOI: 10.3390/ph10010011

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