Article
Generation of protein kinase Ck1alpha mutants which discriminate between canonical and non-canonical substrates.
The Biochemical journal - 15 Oct 2005
Bustos Victor H, Marin Oriano, Meggio Flavio, Cesaro Luca, Allende Catherine C, Allende Jorge E, Pinna Lorenzo A
Abstract excerpt
Protein kinase CK1 denotes a family of pleiotropic serine/threonine protein kinases implicated in a variety of cellular functions. Typically, CK1 acts as a 'phosphate-directed' kinase whose targeting is primed by a single phosphorylated side chain at position n-3 or n-4 relative to serine/threonine, but increasing evidence is accumulating that CK1 can also engage some of its substrates at sites that do not...
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