Article
Effects of oncogenic p110alpha subunit mutations on the lipid kinase activity of phosphoinositide 3-kinase.
The Biochemical journal - 15 Jan 2008
Carson Jeffrey D, Van Aller Glenn, Lehr Ruth, Sinnamon Robert H, Kirkpatrick Robert B, Auger Kurt R, Dhanak Dashyant, Copeland Robert A, Gontarek Richard R, Tummino Peter J, Luo Lusong
Abstract excerpt
The PIK3CA gene, encoding the p110alpha catalytic subunit of Class IA PI3Ks (phosphoinositide 3-kinases), is frequently mutated in many human tumours. The three most common tumour-derived alleles of p110alpha, H1047R, E542K and E545K, were shown to potently activate PI3K signalling in human epithelial cells. In the present study, we examine the biochemical activity of the recombinantly purified PI3K oncogenic...
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