Article

Autophosphorylation of the CK1 kinase domain regulates enzyme activity and function

2019-06-05

Abstract excerpt

CK1 enzymes are conserved, acidophilic serine/threonine kinases with a variety of critical cellular functions; misregulation of CK1 contributes to cancer, neurodegenerative diseases, and sleep phase disorders. Despite this, little is known about how CK1 activity is controlled. Here, we describe a new mechanism of CK1 autoregulation that is conserved in CK1 enzymes from yeast to human – the autophosphorylation of a...

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Literature Corpus work: 41876229-a442-541b-b5e2-c0e660dc9a7b
DOI: 10.1101/660548

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