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Article

Impact of sequence variation in the UL128 locus on production of human cytomegalovirus in fibroblast and epithelial cells.

Journal of virology - 1 Oct 2013

Murrell Isa, Tomasec Peter, Wilkie Gavin S, Dargan Derrick J, Davison Andrew J, Stanton Richard J

Abstract excerpt

The human cytomegalovirus (HCMV) virion envelope contains a complex consisting of glycoproteins gH and gL plus proteins encoded by the UL128 locus (UL128L): pUL128, pUL130, and pUL131A. UL128L is necessary for efficient infection of myeloid, epithelial, and endothelial cells but limits replication in fibroblasts. Consequently, disrupting mutations in UL128L are rapidly selected when clinical isolates are cultured...

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Source

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Identifiers

PMID: 23885075
DOI: 10.1128/JVI.01546-13
PMCID: PMC3807394

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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