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Article

Human cytomegalovirus: taking the strain.

Medical microbiology and immunology - 1 Jun 2015

Wilkinson Gavin W G, Davison Andrew J, Tomasec Peter, Fielding Ceri A, Aicheler Rebecca, Murrell Isa, Seirafian Sepher, Wang Edward C Y, Weekes Michael, Lehner Paul J, Wilkie Gavin S, Stanton Richard J

Abstract excerpt

In celebrating the 60th anniversary of the first isolation of human cytomegalovirus (HCMV), we reflect on the merits and limitations of the viral strains currently being used to develop urgently needed treatments. HCMV research has been dependent for decades on the high-passage strains AD169 and Towne, heavily exploiting their capacity to replicate efficiently in fibroblasts. However, the genetic integrity of...

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Identifiers

PMID: 25894764
DOI: 10.1007/s00430-015-0411-4
PMCID: PMC4439430

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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