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Article

Increased infectivity of human cytomegalovirus strain TB40/E conferred by variants of the envelope glycoprotein UL128 and the regulatory protein IE2.

Journal of virology - 23 Sept 2025

Zhou Xuan, Yang Linjiang, Cimato Giorgia, Frascaroli Giada, Águeda-Pinto Ana, Hertel Laura, Brune Wolfram

Abstract excerpt

Human cytomegalovirus (HCMV) infects various cell types in its human host, and this broad tropism plays a vital role in viral transmission, dissemination, and pathogenesis. HCMV strains differ in their ability to infect and replicate in different cell types, but the genetic determinants of cell tropism have only begun to be understood. A widely used HCMV strain, TB40/E, contains a mixture of genetically distinct...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 40788013
DOI: 10.1128/jvi.00642-25
PMCID: PMC12455921

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