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Article

The human cytomegalovirus UL133-138 gene locus attenuates the lytic viral cycle in fibroblasts.

PloS one - 1 Jan 2015

Dutta Nirmal, Lashmit Philip, Yuan Jinxiang, Meier Jeffery, Stinski Mark F

Abstract excerpt

The genomes of HCMV clinical strains (e.g. FIX, TR, PH, etc) contain a 15 kb region that encodes 20 putative ORFs. The region, termed ULb', is lost after serial passage of virus in human foreskin fibroblast (HFF) cell culture. Compared to clinical strains, laboratory strains replicate faster and to higher titers of infectious virus. We made recombinant viruses with 22, 14, or 7 ORFs deleted from the ULb' region...

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Identifiers

PMID: 25799165
DOI: 10.1371/journal.pone.0120946
PMCID: PMC4370700

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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