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Mutagenesis of human cytomegalovirus glycoprotein L disproportionately disrupts gH/gL/gO over gH/gL/pUL128-131

2021-04-10

Abstract excerpt

<h4>ABSTRACT</h4> Cell-free and cell-to-cell spread of herpesviruses involves a core fusion apparatus comprised of the fusion protein glycoprotein B (gB) and the regulatory factor gH/gL. The human cytomegalovirus (HCMV) gH/gL/gO and gH/gL/pUL128-131 facilitate spread in different cell types. The gO and pUL128-131 components bind distinct receptors, but the how the gH/gL portion of the complexes functionally compa...

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Literature Corpus work
e8479951-4530-517f-991f-27eaa98981d2
DOI
10.1101/2021.04.09.439256
Open publication

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Mutagenesis of human cytomegalovirus glycoprotein L disproportionately disrupts gH/gL/gO over gH/gL/pUL128-131DOI 10.1101/2021.04.09.439256
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