Article

Human cytomegalovirus glycoprotein variants governing viral tropism and syncytium formation in epithelial cells and macrophages

2024-02-13

Abstract excerpt

Human cytomegalovirus (HCMV) displays a broad cell tropism, and the infection of biologically relevant cells such as epithelial, endothelial, and hematopoietic cells supports viral transmission, systemic spread, and pathogenesis in the human host. HCMV strains differ in their ability to infect and replicate in these cell types, but the genetic basis of these differences has remained incompletely understood. In thi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8b00e53c-5f7a-58d2-a168-b438b8b4e2de
DOI: 10.1101/2024.02.12.580040

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human cytomegalovirus glycoprotein variants governing viral tropism and syncytium formation in epithelial cells and macrophagesDOI 10.1101/2024.02.12.580040Read

Human cytomegalovirus glycoprotein variants governing viral tropism and syncytium formation in epithelial cells and macrophagesSemantic proximity Read

Impact of sequence variation in the UL128 locus on production of human cytomegalovirus in fibroblast and epithelial cells.Semantic proximity Read

A Virus Genetic System To Analyze the Fusogenicity of Human Cytomegalovirus Glycoprotein B VariantsSemantic proximity Read

Increased infectivity of human cytomegalovirus strain TB40/E conferred by variants of the envelope glycoprotein UL128 and the regulatory protein IE2.Semantic proximity Read

Increased Infectivity of Human Cytomegalovirus Strain TB40/E Conferred by Variants of the Envelope Glycoprotein UL128 and the Regulatory Protein IE2Semantic proximity Read

Human Cytomegalovirus pUS27 G Protein-Coupled Receptor Homologue Is Required for Efficient Spread by the Extracellular Route but Not for Direct Cell-to-Cell SpreadSemantic proximity Read

Cell Fusion and Syncytium Formation in Betaherpesvirus InfectionSemantic proximity Read

Human cytomegalovirus virion protein complex required for epithelial and endothelial cell tropismSemantic proximity Read

Mutagenesis of human cytomegalovirus glycoprotein L disproportionately disrupts gH/gL/gO over gH/gL/pUL128-131Semantic proximity Read

Genome sequences of human cytomegalovirus strain TB40/E variants propagated in fibroblasts and epithelial cellsSemantic proximity Read

Human cytomegalovirus entry into epithelial and endothelial cells depends on genes UL128 to UL150 and occurs by endocytosis and low-pH fusion.Semantic proximity Read

Genome sequences of human cytomegalovirus strain TB40/E variants propagated in fibroblasts and epithelial cellsSemantic proximity Read