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Genome sequences of human cytomegalovirus strain TB40/E variants propagated in fibroblasts and epithelial cells

3 Jun 2021

Abstract excerpt

The advent of whole genome sequencing has revealed that common laboratory strains of human cytomegalovirus (HCMV) have major genetic deficiencies resulting from serial passage in fibroblasts. In particular, tropism for epithelial and endothelial cells is lost due to mutations disrupting genes UL128, UL130, or UL131A, which encode subunits of a virion-associated pentameric complex (PC) important for viral entry...

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PMID: 34082757
DOI: 10.1186/s12985-021-01583-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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