Article

Genome sequences of human cytomegalovirus strain TB40/E variants propagated in fibroblasts and epithelial cells

2021-04-14

Abstract excerpt

<title>Abstract</title> <p>The advent of whole genome sequencing has revealed that common laboratory strains of human cytomegalovirus (HCMV) have major genetic deficiencies resulting from serial passage in fibroblasts. In particular, tropism for epithelial and endothelial cells is lost due to mutations disrupting genes <italic>UL128</italic>, <italic>UL130</italic>, or <italic>UL131A</italic>, which encode subuni...

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Literature Corpus work: d0b18b73-3d93-5c4f-bad5-91bb307069e3
DOI: 10.21203/rs.3.rs-380905/v1

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