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Article

Transglutaminase-catalyzed protein-protein cross-linking suppresses the activity of the NF-κB-like transcription factor relish.

Science signaling - 23 Jul 2013

Shibata Toshio, Sekihara Sanae, Fujikawa Takumi, Miyaji Ryuta, Maki Kouki, Ishihara Takeshi, Koshiba Takumi, Kawabata Shun-ichiro

Abstract excerpt

Cross-linking of proteins by mammalian transglutaminases (TGs) plays important roles in physiological phenomena such as blood coagulation and skin formation. We show that Drosophila TG suppressed innate immune signaling in the gut. RNA interference (RNAi) directed against TG reduced the life span of flies reared under conventional nonsterile conditions but not of those raised under germ-free conditions. In...

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PMID: 23882120
DOI: 10.1126/scisignal.2003970

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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