Article
Requirement for a peptidoglycan recognition protein (PGRP) in Relish activation and antibacterial immune responses in Drosophila.
Science (New York, N.Y.) - 12 Apr 2002
Choe Kwang-Min, Werner Thomas, Stöven Svenja, Hultmark Dan, Anderson Kathryn V
Abstract excerpt
Components of microbial cell walls are potent activators of innate immune responses in animals. For example, the mammalian TLR4 signaling pathway is activated by bacterial lipopolysaccharide and is required for resistance to infection by Gram-negative bacteria. Other components of microbial surfaces, such as peptidoglycan, are also potent activators of innate immune responses, but less is known about how those...
Topics
- Active Transport, Cell Nucleus
- Alternative Splicing
- Animals
- Antimicrobial Cationic Peptides
- Carrier Proteins
- Cell Nucleus
- Drosophila
- Drosophila Proteins
- Escherichia coli
- Exons
- Expressed Sequence Tags
- Gene Expression Regulation
- Genes, Insect