Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Protein crosslinking by transglutaminase controls cuticle morphogenesis in Drosophila.

PloS one - 18 Oct 2010

Shibata Toshio, Ariki Shigeru, Shinzawa Naoaki, Miyaji Ryuta, Suyama Haruka, Sako Miyuki, Inomata Nobuyuki, Koshiba Takumi, Kanuka Hirotaka, Kawabata Shun-Ichiro

Abstract excerpt

Transglutaminase (TG) plays important and diverse roles in mammals, such as blood coagulation and formation of the skin barrier, by catalyzing protein crosslinking. In invertebrates, TG is known to be involved in immobilization of invading pathogens at sites of injury. Here we demonstrate that Drosophila TG is an important enzyme for cuticle morphogenesis. Although TG activity was undetectable before the second...

Topics

Animals
Drosophila
Drosophila Proteins
Larva
Morphogenesis
Phenotype
RNA Interference
Substrate Specificity
Transglutaminases

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Open in PubMed Open full text

Identifiers

PMID: 20976106
DOI: 10.1371/journal.pone.0013477
PMCID: PMC2956697

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Protein crosslinking by transglutaminase controls cuticle morphogenesis in Drosophila.PMID 20976106Read ↗

Transglutaminase-catalyzed protein-protein cross-linking suppresses the activity of the NF-κB-like transcription factor relish.Semantic proximity Read ↗

Involvement of chitin in exoskeleton morphogenesis in Drosophila melanogaster.Semantic proximity Read ↗

Inhibition of transglutaminase exacerbates polyglutamine-induced neurotoxicity by increasing the aggregation of mutant ataxin-3 in an SCA3 Drosophila model.Semantic proximity Read ↗

Imaginal disc growth factors are <i>Drosophila</i> Chitinase-like Proteins with roles in morphogenesis and CO <sub>2</sub> responseSemantic proximity Read ↗

Over-expression of transglutaminase in the Drosophila eye imaginal disc induces a rough eye phenotype.Semantic proximity Read ↗

Group I chitin deacetylases are essential for higher order organization of chitin fibers in beetle cuticle.Semantic proximity Read ↗

Functional specialization among insect chitinase family genes revealed by RNA interference.Semantic proximity Read ↗

A homolog of Drosophila grainy head is essential for epidermal integrity in mice.Semantic proximity Read ↗

Isolation and functional identification of three cuticle protein genes during metamorphosis of the beet armyworm, Spodoptera exigua.Semantic proximity Read ↗

Transglutaminases and disease: lessons from genetically engineered mouse models and inherited disorders.Semantic proximity Read ↗

Physiological Characterization of the Chitin Synthase A Gene Responsible for Biosynthesis of Cuticle Chitin in Culex Pipiens Pallens (Diptera: Culicidae)Semantic proximity Read ↗

Biosynthesis and enzymology of the Caenorhabditis elegans cuticle: identification and characterization of a novel serine protease inhibitor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.