Article
Importance of lipid-pore loop interface for potassium channel structure and function.
Proceedings of the National Academy of Sciences of the United States of America - 6 Aug 2013
van der Cruijsen Elwin A W, Nand Deepak, Weingarth Markus, Prokofyev Alexander, Hornig Sönke, Cukkemane Abhishek Arun, Bonvin Alexandre M J J, Becker Stefan, Hulse Raymond E, Perozo Eduardo, Pongs Olaf, Baldus Marc
Abstract excerpt
Potassium (i.e., K(+)) channels allow for the controlled and selective passage of potassium ions across the plasma membrane via a conserved pore domain. In voltage-gated K(+) channels, gating is the result of the coordinated action of two coupled gates: an activation gate at the intracellular entrance of the pore and an inactivation gate at the selectivity filter. By using solid-state NMR structural studies, in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.