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Article

Pore dynamics and conductance of RyR1 transmembrane domain.

Biophysical journal - 3 Jun 2014

Shirvanyants David, Ramachandran Srinivas, Mei Yingwu, Xu Le, Meissner Gerhard, Dokholyan Nikolay V

Abstract excerpt

Ryanodine receptors (RyR) are calcium release channels, playing a major role in the regulation of muscular contraction. Mutations in skeletal muscle RyR (RyR1) are associated with congenital diseases such as malignant hyperthermia and central core disease (CCD). The absence of high-resolution structures of RyR1 has limited our understanding of channel function and disease mechanisms at the molecular level....

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Identifiers

PMID: 24896116
DOI: 10.1016/j.bpj.2014.04.023
PMCID: PMC4052289

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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