Improved identification of von Hippel-Lindau gene alterations in clear cell renal tumors.

doi:10.1158/1078-0432.CCR-07-4921

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Article

Improved identification of von Hippel-Lindau gene alterations in clear cell renal tumors.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2008

Nickerson Michael L, Jaeger Erich, Shi Yangu, Durocher Jeffrey A, Mahurkar Sunil, Zaridze David, Matveev Vsevolod, Janout Vladimir, Kollarova Hellena, Bencko Vladimir, Navratilova Marie, Szeszenia-Dabrowska Neonilia, Mates Dana, Mukeria Anush, Holcatova Ivana, Schmidt Laura S, Toro Jorge R, Karami Sara, Hung Rayjean, Gerard Gary F, Linehan W Marston, Merino Maria, Zbar Berton, Boffetta Paolo, Brennan Paul, Rothman Nathaniel, Chow Wong-Ho, Waldman Frederic M, Moore Lee E

Abstract excerpt

PURPOSE: To provide a comprehensive, thorough analysis of somatic mutation and promoter hypermethylation of the von Hippel-Lindau (VHL) gene in the cancer genome, unique to clear cell renal cancer (ccRCC). Identify relationships between the prevalence of VHL gene alterations and alteration subtypes with patient and tumor characteristics. EXPERIMENTAL DESIGN: As part of a large kidney cancer case-control study...

Topics

Adenocarcinoma, Clear Cell
Carcinoma, Renal Cell
Case-Control Studies
CpG Islands
DNA Methylation
Female
Gene Expression Profiling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Regulation, Neoplastic

Humans

Kidney Neoplasms

Male

Mutation

Neoplasms

Promoter Regions, Genetic

Von Hippel-Lindau Tumor Suppressor Protein

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Identifiers

PMID: 18676741
DOI: 10.1158/1078-0432.CCR-07-4921
PMCID: PMC2629664

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