Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

von Hippel-Lindau gene status and response to vascular endothelial growth factor targeted therapy for metastatic clear cell renal cell carcinoma.

The Journal of urology - 1 Sept 2008

Choueiri Toni K, Vaziri Susan A J, Jaeger Erich, Elson Paul, Wood Laura, Bhalla Ish Prasad, Small Eric J, Weinberg Vivian, Sein Nancy, Simko Jeff, Golshayan Ali-Reza, Sercia Linda, Zhou Ming, Waldman Frederic M, Rini Brian I, Bukowski Ronald M, Ganapathi Ram

Abstract excerpt

PURPOSE: The von Hippel-Lindau (VHL) gene is often inactivated (by mutation or promoter hypermethylation) in renal cell carcinoma but the relation to therapeutic outcome is unclear. MATERIALS AND METHODS: Patients with metastatic clear cell renal cell carcinoma with available baseline tumor samples who received vascular endothelial growth factor targeted therapy were included in analysis. Patient characteristics,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzenesulfonates
Share to Bevacizumab

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Indazoles

Share to Niacinamide

Share to Phenylurea Compounds

Share to Sorafenib

Share to Sunitinib

Share to von Hippel-Lindau Disease

Source

Identifiers

PMID: 18635227
DOI: 10.1016/j.juro.2008.05.015

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

von Hippel-Lindau gene status and response to vascular endothelial growth factor targeted therapy for metastatic clear cell renal cell carcinoma.PMID 18635227Read ↗

Clinical response to therapy targeted at vascular endothelial growth factor in metastatic renal cell carcinoma: impact of patient characteristics and Von Hippel-Lindau gene status.Semantic proximity Read ↗

The role of aberrant VHL/HIF pathway elements in predicting clinical outcome to pazopanib therapy in patients with metastatic clear-cell renal cell carcinoma.Semantic proximity Read ↗

Polymorphisms in the Von Hippel-Lindau Gene Are Associated With Overall Survival in Metastatic Clear-Cell Renal-Cell Carcinoma Patients Treated With VEGFR Tyrosine Kinase Inhibitors.Semantic proximity Read ↗

Improved identification of von Hippel-Lindau gene alterations in clear cell renal tumors.Semantic proximity Read ↗

VHL mutations and their correlation with tumour cell proliferation, microvessel density, and patient prognosis in clear cell renal cell carcinoma.Semantic proximity Read ↗

Somatic VHL alteration and its impact on prognosis in patients with clear cell renal cell carcinomaSemantic proximity Read ↗

Genetic and epigenetic alterations in the von hippel-lindau gene: the influence on renal cancer prognosis.Semantic proximity Read ↗

Implication of VHL, ERK5, and HIF-1alpha in clear cell renal cell carcinoma: Molecular basis.Semantic proximity Read ↗

Clinicopathologic Significance of VHL Gene Alteration in Clear-Cell Renal Cell Carcinoma: An Updated Meta-Analysis and Review.Semantic proximity Read ↗

Mutational status of VHL gene and its clinical importance in renal clear cell carcinoma.Semantic proximity Read ↗

Genetic pathways involved in carcinogenesis of clear cell renal cell carcinoma: genomics towards personalized medicine.Semantic proximity Read ↗

VHL tumor suppressor gene alterations associated with good prognosis in sporadic clear-cell renal carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.